TOPIC: RANDOM MIX
A 10-month-old infant presents with irritability, bleeding gums, and exquisitely tender lower extremities. Radiographs reveal a ‘Frankel line’ and a ‘Wimberger ring’ at the epiphyses. The underlying metabolic defect in this condition is a failure of:
A
Osteoclastic bone resorption
B
Mineralization of osteoid matrix
C
Hydroxylation of proline and lysine residues in collagen
D
Production of 1,25-dihydroxyvitamin D