TOPIC: RANDOM MIX
Vitamin C deficiency (scurvy) directly impairs which of the following steps in the synthesis of type I collagen, leading to bone fragility, subperiosteal hemorrhages, and metaphyseal changes (Pelkan spur)?
A
Cleavage of procollagen C- and N-terminals
B
Intracellular transport of pro-alpha chains
C
Hydroxylation of proline and lysine residues
D
Cross-linking of tropocollagen molecules by lysyl oxidase