TOPIC: RANDOM MIX
In the pathogenesis of periprosthetic joint infection (PJI), Staphylococcus epidermidis primarily utilizes which of the following mechanisms to confer profound resistance to host immune clearance and systemic antibiotics?
A
Intracellular survival within host osteoblasts
B
Elaboration of Panton-Valentine leukocidin (PVL) to directly destroy macrophages
C
Production of a polysaccharide intercellular adhesin (PIA) to form a protective biofilm
D
Secretion of beta-lactamase directly onto the implant surface