TOPIC: RANDOM MIX
A child presents with genu varum, widened growth plates, and metaphyseal cupping. Labs show low vitamin D and elevated alkaline phosphatase. What is the underlying pathophysiology?
A
Defective osteoclast resorption
B
Failure of mineralization of osteoid at growth plate
C
Increased osteoblastic proliferation
D
Excess calcitonin secretion