TOPIC: RANDOM MIX
A 15-year-old boy presents with aching leg pain that worsens at night and is dramatically relieved by the administration of oral ibuprofen. Radiographs reveal a small radiolucent nidus surrounded by dense reactive sclerosis in the tibial diaphysis. What is the most characteristic biochemical mediator produced by this nidus?
A
Prostaglandin E2
B
Interleukin-1
C
Tumor Necrosis Factor-alpha
D
Transforming Growth Factor-beta